Orochimaru still maintains his original form – having ashen skin with waist-length black hair. He has amber eyes with slits in his pupils and purple markings around his eyes — a reference to his snake-like nature.
Orochimaru's various human experiments took place to serve two purposes, most prominent of which was his desire to learn every technique in the world. Many people, including Tsunade, often referred to him as "the twisted one". Jiraiya speculated that this was since both of his parents died when he was at a very young age, and flashbacks showed during his battle with the Third Hokage speak to this effect.
Orochimaru can use many snake-related abilities such as Snake Fist, Hidden Shadow Snake Hands, and many more.
Orochimaru can summon Manda the giant snake to help him if he is in a dire situation.
- In Episode 21, Orochimaru and Kabuto quoted Team Rocket's phrase: "We're Blasting Off Again."
- Orochimaru is also surprisingly sensitive, as seen in episode 15, where acts out a sad story to make everyone cry, and fill the empty pool with it. Orochimaru ends up the only one crying.
- In Episode 48, Orochimaru mentioned that the forty-seven episodes and the series are almost over.